ENTER.HUB promotes the role of railway hubs/multimodal interfaces of regional relevance in medium cities as engines for integrated urban development and economic, social and cultural regeneration. The network of local actors will redefine territorial/functional systems around these hubs, by exploiting these “agglomerates of flows” to strengthen connectivity at a local/ regional/ EU level for cities to become more competitive, to attract population and business in the face of the economic crisis.