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TRIMIS

Transport derived Ultrafines and the Brain Effects

TUBE

Transport derived Ultrafines and the Brain Effects

Link to CORDIS:
Objectives: 

The aim of the research is to study the effects of smallest traffic related ultrafine- or nanoparticles beyond the lung on brain health. Air pollutants have been shown to cause a vast amount of different adverse health effects. These effects include impairment of many respiratory (e.g. asthma, COPD) and cardiovascular (ischemic heart disease, infarction, stroke) diseases. However, in recent years, the evidence showing effects beyond the lungs and circulatory system are becoming more evident.

Neurological diseases, namely Alzheimer´s disease (AD) has shown to be associated with living near traffic. However, reason for this has remained unresolved until today. This consortium aims on revealing the mechanisms and exposures both behind cardiorespiratory diseases and beyond the current knowledge in neurological diseases. This consortium includes experts in areas of aerosol technology, emission research, engine and fuel research, human clinical studies, epidemiology, emission inventories, inhalation toxicology, neurotoxicology and disease mechanism studies. This enables research of resolving the effects of nanoparticles from different traffic modes for both air quality and concomitant toxic effect of these air pollutants.

In this study, we will investigate adverse effects of air pollutants using cell cultures, animal exposures and volunteered human exposures as well as the material from epidemiological cohort study. These are going to be compared according to inflammatory, cytotoxic and genotoxic changes and furthermore beyond the current state of the art to neurotoxic and brain health effects.

With this approach, we are aiming in to a comprehensive understanding of the adverse effects of nanoparticles from traffic. In current situations, only particles above 23nm are measured in regulations, traditional toxicological methods are used in risk assessment and emission inventories and regulations are largely based on old technology engines. Our project will change this.

Institution Type:
Institution Name: 
European Commission
Type of funding:
Programme Other: 
LC-MG-1-1-2018 InCo flagship on reduction of transport impact on air quality
Lead Organisation: 

Ita-Suomen Yliopisto

Address: 
Yliopistonranta 1 E
70211 Kuopio
Finland
EU Contribution: 
€891,170
Partner Organisations: 

Mimetas Bv

Address: 
JH Oortweg 19
2333CH Leiden
Netherlands
EU Contribution: 
€400,393

Teknologian Tutkimuskeskus Vtt Oy

Address: 
VUORIMIEHENTIE 3
02150 Espoo
Finland
EU Contribution: 
€520,086

Kobenhavns Universitet

Address: 
Norregade 10
1165 København
Denmark
EU Contribution: 
€294,467

Ustav Experimentalni Mediciny Akademie Ved Ceske Republiky Verejna Vyzkumna Instituce

Address: 
VIDENSKA 1083
14220 PRAHA 4
Czech Republic
EU Contribution: 
€337,772

Biotalentum Tudasfejleszto Kft

Address: 
AULICH LAJOS UTCA 26
GOEDOELLO
2100
Hungary
EU Contribution: 
€361,875

Institut Fur Umweltmedizinische Forschung An Der Heinrich-Heine-Universitat Dusseldorf Gmbh

Address: 
AUF M HENNEKAMP 50
40225 DUESSELDORF
Germany
EU Contribution: 
€403,040

Sun Yat-Sen University

Address: 
West Xin Gang Road, 135
GUANGZHOU
510275
China
EU Contribution: 
€0

Tampereen Korkeakoulusaatio Sr

Address: 
KALEVANTIE 4
33100 TAMPERE
Finland
EU Contribution: 
€337,087

Umea Universitet

Address: 
UNIVERSITETOMRADET
901 87 UMEA
Sweden
EU Contribution: 
€262,625

Vsparticle Bv

Address: 
MOLENGRAAFFSINGEL 10, 2DE VERDIEPING
2629 JD DELFT
Netherlands
EU Contribution: 
€110,887

University Of Southampton

Address: 
Highfield
Southampton
SO17 1BJ
United Kingdom
EU Contribution: 
€232,868

Ilmatieteen Laitos

Address: 
Erik Palmenin aukio 1
00560 HELSINKI
Finland
EU Contribution: 
€220,000

Universiteit Utrecht

Address: 
Heidelberglaan 8
3584 CS Utrecht
Netherlands
EU Contribution: 
€578,856

Centro Premio Nobel Mario Molina Para Estudios Estrategicos Sobre Energia Y Medio Ambiente Chile Limitada

Address: 
ANTONIO BELLET 292, 602 PROVIDENCIA
8320000 SANTIAGO DE CHILE
Chile
EU Contribution: 
€98,750
Technologies: