Safety and resilience are fundamental requirements of transport and mobility, and as such are key objectives of the Sustainable and Smart Mobility Strategy of the European Commission, adopted in 2021 as part of the EU Green Deal. Research and Innovation is crucial to achieve EU transport safety and resilience objectives. Projects funded by the European Framework Programmes perform the background analysis and develop the technologies and the means for safety and resilience management. They also propose improvements for regulations and conceive procedures for their enforcement. Finally, they provide insights on human behaviour and develop innovative training to raise awareness and promote a safety culture. EU research and innovation therefore addresses all three pillars of safety and resilience: technologies, regulations and human factors, in a collaborative and inclusive framework. The aim of this report is to analyse the main trends, challenges, and achievements of European research and innovation in Transport Safety and Resilience, and to give recommendations on future initiatives. The report uses the Transport Research and Innovation Monitoring and Information System (TRIMIS) database to identify relevant projects.